Home 2015 - Volume 15 (3) PREVALENCE AND RISK FACTORS OF PREMATURE CORONARY ARTERY DISEASE: A COMPARATIVE CROSS-SECTIONAL STUDY BETWEEN TWO TIME FRAMES IN MALAYSIA
PREVALENCE AND RISK FACTORS OF PREMATURE CORONARY ARTERY DISEASE: A COMPARATIVE CROSS-SECTIONAL STUDY BETWEEN TWO TIME FRAMES IN MALAYSIA PDF Print E-mail
Monday, 07 September 2015 07:51

Shamsul Azhar Shah1,3, Lee Jing2, Muhammad Syahmi Khalid2, Fatimah Najid2, Intan Sabrina Haniff2, Azmee Mohd Ghazi4, Ika Faizura Mohd Nor4, Rosli Mohd Ali4 and Wan  Zurinah Wan Ngah2,3

1Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

2Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

3UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

4National Heart Institute, Kuala Lumpur, Malaysia

ABSTRACT

Limited studies on prevalence and risk factors of Premature Coronary Artery Disease (PCAD) were done in Malaysia, primarily on lipid profile. This cross sectional study aims to identify any changing patterns in prevalence and risk factors of Premature CAD between 2000 and 2012. From 2000 to 2012 we included 21862 patients who underwent the first Percutaneous Coronary Intervention (PCI).  Analysis of risk factors was done to 1660 and 2098 patients from year 2007 and 2012 respectively. Age of less than 45 years was taken as PCAD. Data was collected from PCI database of National Heart Institute (NHI), NHI TrakCare System, and patients’ medical records. PCAD significantly decreased from 18.8% (2000) to 11.6% (2012). Malay ethnicity showed increasing trend over the years from 55.1% to 66.9%. Multiple logistic regression analysis in 2007 showed that smoking had the higher risk (AOR=2.52), followed by male gender (AOR=2.06), family history of PCAD (AOR=1.96), Indian ethnicity, (AOR=1.65), triglycerides level (AOR=1.20) and BMI (AOR=1.06). In 2012, family history of PCAD had the highest risk (AOR=2.00) followed by smoking (AOR=1.91) and BMI (AOR=1.11). There are changes in risk factors patterns of premature CAD between 2007 and 2012. Most of them are preventable at earlier stage.

Keywords: Premature Coronary Artery Disease, risk factors, prevalence.

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Last Updated on Monday, 07 September 2015 07:54
 

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ISSN No : 1675-0306
e-ISSN No : 2590-3829

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