Home 2017 - Volume 17 (3) IMPACT OF KHAT (CATHA EDULIS) CHEWING/USE ON HEART RATE AND BLOOD PRESSURE: A CRITICAL REVIEW
IMPACT OF KHAT (CATHA EDULIS) CHEWING/USE ON HEART RATE AND BLOOD PRESSURE: A CRITICAL REVIEW PDF Print E-mail
Monday, 11 December 2017 10:41

Zhi Xiong Chong1, Mustafa Alshagga1*, Khaled Ahmed Saed2 and Saba Kassim3

1Department of Biomedical Science, Faculty of Science, University of Nottingham Malaysia Campus, Semenyih, Malaysia

2Department of Surgery, Faculty of Medicine, Aden University, Yemen

3Taibah University Dental College and Hospital (TUDCH), Al-Madinah Al-Munawwarah, Saudi Arabia

Corresponding author:

*Mustafa Alshagga

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ABSTRACT

Khat leaves chewing/use, which imparts amphetamine like effects on the user, is widely practiced in parts of Africa, the Arabian Peninsula, and among the diaspora communities from these regions. Basic clinical and epidemiological studies from different settings have reported associations of acute coronary syndrome, heart failure, and cardiomyopathy, with khat chewing /use. This review aims to analyse the current evidence of the impact that khat, or its active constituent, cathinone, has on the cardiovascular system (CVS), particularly in two parameters, heart rate (HR) and blood pressure (BP). Subsequently, the possible mechanism of actions of how khat impacts these cardiovascular parameters is discussed, and different studies’ findings are summarised appropriately. The analysis of literature suggests that khat could influence HR and BP by most likely causing tachycardia and hypertension and the impacts might be dose-dependent and time-dependent. However, most of the studies involved different species and study designs, and had different limitations. Additionally, the underlying mechanisms of khat effects on these CVS parameters remain unclear. Therefore, more studies are needed to further support the current evidence of the impacts that khat has on the CVS parameters of HR and BP.

 

Keywords: Khat, cardiovascular system (CVS), heart rate, blood pressure, cathinone, Review

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Last Updated on Monday, 11 December 2017 10:42